Herpes simplex virus genome isomerization: origins of adjacent long segments in concatemeric viral DNA.
نویسندگان
چکیده
Herpes simplex virus type 1 DNA isomerization was studied by using a viral mutant, 5B8, lacking the unique SpeI site of its parent, SC16. In coinfected cells, SC16 genomic long segments flanked 5B8 genomes in all possible orientations with similar frequencies. Thus, recombination between progeny of different replication templates is sufficient to explain genomic isomerization.
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ورودعنوان ژورنال:
- Journal of virology
دوره 73 1 شماره
صفحات -
تاریخ انتشار 1999